Dibotermin alfa
Inductos (dibotermin alfa) is a protein pharmaceutical. Dibotermin alfa was first approved as Inductos on 2002-09-09. It has been approved in Europe to treat internal fracture fixation, spinal fusion, and tibial fractures.
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Indications Phases 4
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Bone fractures | D050723 | EFO_0003931 | T14.8 | 1 | 3 | 1 | 3 | 1 | 8 |
| Spondylosis | D055009 | — | M47 | 1 | 1 | 1 | 1 | 3 | 6 |
| Tibial fractures | D013978 | EFO_0003944 | S82.20 | — | 1 | 1 | 2 | — | 3 |
| Cleft lip | D002971 | EFO_0003959 | Q36 | — | — | — | 1 | — | 1 |
Indications Phases 3
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Intervertebral disc degeneration | D055959 | HP_0008419 | — | 1 | 1 | 1 | — | 20 | 22 |
| Tooth loss | D016388 | — | — | — | — | 1 | — | — | 1 |
| Anodontia | D000848 | HP_0000668 | K00.0 | — | — | 1 | — | — | 1 |
| Wound healing | D014945 | GO_0042060 | — | — | — | 1 | — | — | 1 |
Indications Phases 2
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Spinal diseases | D013122 | — | M45-M49 | 1 | 1 | — | — | 9 | 10 |
| Periodontitis | D010518 | EFO_0000649 | K05.3 | — | 1 | — | — | 2 | 3 |
| Closed fractures | D005596 | — | — | — | 1 | — | — | 1 | 2 |
| Osteoporosis | D010024 | HP_0000939 | M81.0 | — | 1 | — | — | 1 | 2 |
| Malocclusion | D008310 | HP_0000689 | M26.4 | — | 1 | — | — | — | 1 |
| Ununited fractures | D005599 | — | — | — | 1 | — | — | — | 1 |
| Humeral fractures | D006810 | EFO_0003943 | S42.3 | — | 1 | — | — | — | 1 |
| Swine diseases | D013553 | — | — | 1 | 1 | — | — | — | 1 |
Indications Phases 1
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Hypertension | D006973 | EFO_0000537 | I10 | 1 | — | — | — | 1 | 2 |
| Osteoarthritis | D010003 | EFO_0002506 | M15-M19 | 2 | — | — | — | — | 2 |
| Bunion | D000071378 | — | M21.61 | 1 | — | — | — | — | 1 |
| Bone diseases | D001847 | — | M89.9 | 1 | — | — | — | — | 1 |
| Radius fractures | D011885 | EFO_0003957 | — | 1 | — | — | — | — | 1 |
| Wrist fractures | D000092503 | — | — | 1 | — | — | — | — | 1 |
| Diabetes mellitus | D003920 | HP_0000819 | E08-E13 | 1 | — | — | — | — | 1 |
| Hematologic diseases | D006402 | EFO_0005803 | D75.9 | 1 | — | — | — | — | 1 |
Indications Without Phase
Indication | MeSH | Ontology | ICD-10 | Ph 1 | Ph 2 | Ph 3 | Ph 4 | Other | Total |
|---|---|---|---|---|---|---|---|---|---|
| Spondylolisthesis | D013168 | EFO_0007493 | M43.1 | — | — | — | — | 4 | 4 |
| Spinal fusion | D013123 | — | — | — | — | — | — | 3 | 3 |
| Alveolar bone loss | D016301 | — | — | — | — | — | — | 3 | 3 |
| Spinal stenosis | D013130 | EFO_0007490 | M48.0 | — | — | — | — | 2 | 2 |
| Pseudarthrosis | D011542 | — | — | — | — | — | — | 2 | 2 |
| Intervertebral disc displacement | D007405 | EFO_1001800 | — | — | — | — | — | 2 | 2 |
| Alveolar ridge augmentation | D000540 | — | — | — | — | — | — | 2 | 2 |
| Scoliosis | D012600 | EFO_0004273 | M41 | — | — | — | — | 1 | 1 |
| Pulmonary arterial hypertension | D000081029 | — | — | — | — | — | — | 1 | 1 |
| Familial primary pulmonary hypertension | D065627 | — | I27.0 | — | — | — | — | 1 | 1 |
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Epidemiology
Epidemiological information for investigational and approved indications
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Drug
General
| Drug common name | Dibotermin alfa |
| INN | nebotermin |
| Description | Inductos (dibotermin alfa) is a protein pharmaceutical. Dibotermin alfa was first approved as Inductos on 2002-09-09. It has been approved in Europe to treat internal fracture fixation, spinal fusion, and tibial fractures. |
| Classification | Protein |
| Drug class | growth factors: bone morphogenetic proteins; growth factors: transforming growth factors |
| Image (chem structure or protein) |  |
| Structure (InChI/SMILES or Protein Sequence) | — |
Identifiers
| PDB | — |
| CAS-ID | — |
| RxCUI | — |
| ChEMBL ID | CHEMBL2109171 |
| ChEBI ID | — |
| PubChem CID | — |
| DrugBank | — |
| UNII ID | T472P45MG6 (ChemIDplus, GSRS) |
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